Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Bmp4  bone morphogenetic protein 4   (Synonyms: Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4)
Results	Reference
1	J:150706 Abler LL, Mansour SL, Sun X, Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Dev Dyn. 2009 Jul 17;238(8):1999-2013
1	J:106499 Airik R, Bussen M, Singh MK, Petry M, Kispert A, Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest. 2006 Mar;116(3):663-74
1*	J:187602 Al Alam D, Sala FG, Baptista S, Galzote R, Danopoulos S, Tiozzo C, Gage P, Grikscheit T, Warburton D, Frey MR, Bellusci S, FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Dev Biol. 2012 Sep 15;369(2):340-8
1*	J:75699 Albrecht AN, Schwabe GC, Stricker S, Boddrich A, Wanker EE, Mundlos S, The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements. Mech Dev. 2002 Mar;112(1-2):53-67
1	J:152710 Aldinger KA, Lehmann OJ, Hudgins L, Chizhikov VV, Bassuk AG, Ades LC, Krantz ID, Dobyns WB, Millen KJ, FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation. Nat Genet. 2009 Sep;41(9):1037-42
1	J:70592 Arteaga-Solis E, Gayraud B, Lee SY, Shum L, Sakai L, Ramirez F, Regulation of limb patterning by extracellular microfibrils. J Cell Biol. 2001 Jul 23;154(2):275-81
1	J:173382 Basch ML, Ohyama T, Segil N, Groves AK, Canonical Notch Signaling Is Not Necessary for Prosensory Induction in the Mouse Cochlea: Insights from a Conditional Mutant of RBPj{kappa}. J Neurosci. 2011 Jun 1;31(22):8046-58
1	J:283343 Bastida MF, Perez-Gomez R, Trofka A, Zhu J, Rada-Iglesias A, Sheth R, Stadler HS, Mackem S, Ros MA, The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1090-1096
1*	J:80696 Beverdam A, Merlo GR, Paleari L, Mantero S, Genova F, Barbieri O, Janvier P, Levi G, Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: Mirror of the past?. Genesis. 2002 Dec;34(4):221-7
1*	J:39658 Buscher D, Bosse B, Heymer J, Ruther U, Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech Dev. 1997 Mar;62(2):175-82
1	J:153595 Butterfield NC, Metzis V, McGlinn E, Bruce SJ, Wainwright BJ, Wicking C, Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Development. 2009 Oct;136(20):3515-24
1*	J:112220 Caruana G, Cullen-McEwen L, Nelson AL, Kostoulias X, Woods K, Gardiner B, Davis MJ, Taylor DF, Teasdale RD, Grimmond SM, Little MH, Bertram JF, Spatial gene expression in the T-stage mouse metanephros. Gene Expr Patterns. 2006 Dec;6(8):807-25
1	J:91010 Chi L, Zhang S, Lin Y, Prunskaite-Hyyrylainen R, Vuolteenaho R, Itaranta P, Vainio S, Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development. Development. 2004 Jul;131(14):3345-56
1*	J:133691 Choi M, Stottmann RW, Yang YP, Meyers EN, Klingensmith J, The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res. 2007 Feb 2;100(2):220-8
1	J:213642 Cooper KL, Sears KE, Uygur A, Maier J, Baczkowski KS, Brosnahan M, Antczak D, Skidmore JA, Tabin CJ, Patterning and post-patterning modes of evolutionary digit loss in mammals. Nature. 2014 Jul 3;511(7507):41-5
1*	J:42445 Dunn NR, Winnier GE, Hargett LK, Schrick JJ, Fogo AB, Hogan BL, Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev Biol. 1997 Aug 15;188(2):235-47
1	J:218159 Eshkar-Oren I, Krief S, Ferrara N, Elliott AM, Zelzer E, Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism. Development. 2015 Feb 15;142(4):672-80
1*	J:165424 Fuchs A, Inthal A, Herrmann D, Cheng S, Nakatomi M, Peters H, Neubuser A, Regulation of Tbx22 during facial and palatal development. Dev Dyn. 2010 Nov;239(11):2860-74
1	J:136180 Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R, Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol. 2008 May 1;317(1):296-309
1*	J:48569 Grove EA, Tole S, Limon J, Yip L, Ragsdale CW, The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development. 1998 Jun;125(12):2315-25
1	J:78767 Guha U, Gomes W, Kobayashi T, Pestell R, Kessler J, In Vivo Evidence That BMP Signaling Is Necessary for Apoptosis in the Mouse Limb. Dev Biol. 2002 Sep 1;249(1):108
1	J:88594 Guha U, Gomes WA, Samanta J, Gupta M, Rice FL, Kessler JA, Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo. Development. 2004 Mar;131(5):1175-86
1*	J:241980 Guo C, Sun Y, Guo C, MacDonald BT, Borer JG, Li X, Dkk1 in the peri-cloaca mesenchyme regulates formation of anorectal and genitourinary tracts. Dev Biol. 2014 Jan 01;385(1):41-51
1*	J:82630 Hall JM, Bell ML, Finger TE, Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae. Dev Biol. 2003 Mar 15;255(2):263-77
1*	J:125119 Han J, Ishii M, Bringas P Jr, Maas RL, Maxson RE Jr, Chai Y, Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev. 2007 Sep-Oct;124(9-10):729-45
1	J:243204 Han L, Xu J, Grigg E, Slack M, Chaturvedi P, Jiang R, Zorn AM, Osr1 functions downstream of Hedgehog pathway to regulate foregut development. Dev Biol. 2017 Jul 01;427(1):72-83
1	J:106072 Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X, Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2208-13
1	J:58673 Heymer J, Ruther U, Syndactyly of Ft/+ mice correlates with an imbalance in bmp4 and fgf8 expression. Mech Dev. 1999 Nov;88(2):173-81
1	J:276702 Hildebrand L, Schmidt-von Kegler M, Walther M, Seemann P, Stange K, Limb specific Acvr1-knockout during embryogenesis in mice exhibits great toe malformation as seen in Fibrodysplasia Ossificans Progressiva (FOP). Dev Dyn. 2019 May;248(5):396-403
1	J:198291 Huang Y, Kapere Ochieng J, Kempen MB, Munck AB, Swagemakers S, van Ijcken W, Grosveld F, Tibboel D, Rottier RJ, Hypoxia inducible factor 3alpha plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. PLoS One. 2013;8(2):e57695
1*	J:54206 Jung HS, Oropeza V, Thesleff I, Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae. Mech Dev. 1999 Mar;81(1-2):179-82
1	J:189974 Kiefer SM, Robbins L, Rauchman M, Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function. PLoS One. 2012;7(8):e43098
1	J:84901 Kuschel S, Ruther U, Theil T, A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon. Dev Biol. 2003 Aug 15;260(2):484-95
1	J:102949 Li C, Xu X, Nelson DK, Williams T, Kuehn MR, Deng CX, FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis. Development. 2005 Nov;132(21):4755-64
1	J:130228 Liu F, Chu EY, Watt B, Zhang Y, Gallant NM, Andl T, Yang SH, Lu MM, Piccolo S, Schmidt-Ullrich R, Taketo MM, Morrisey EE, Atit R, Dlugosz AA, Millar SE, Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008 Jan 1;313(1):210-24
1	J:57674 Lu MF, Pressman C, Dyer R, Johnson RL, Martin JF, Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Nature. 1999 Sep 16;401(6750):276-8
1*	J:73434 Mailleux AA, Spencer-Dene B, Dillon C, Ndiaye D, Savona-Baron C, Itoh N, Kato S, Dickson C, Thiery JP, Bellusci S, Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development. 2002 Jan;129(1):53-60
1	J:262487 Murgai A, Altmeyer S, Wiegand S, Tylzanowski P, Stricker S, Cooperation of BMP and IHH signaling in interdigital cell fate determination. PLoS One. 2018;13(5):e0197535
1	J:272609 Nantie LB, Young RE, Paltzer WG, Zhang Y, Johnson RL, Verheyden JM, Sun X, Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing. Development. 2018 Nov 9;145(21):dev163105
1	J:235048 Navarro-Garberi M, Bueno C, Martinez S, Wnt1 signal determines the patterning of the diencephalic dorso-ventral axis. Brain Struct Funct. 2016 Sep;221(7):3693-708
1	J:276879 Noe N, Shim A, Millette K, Luo Y, Azhar M, Shi W, Warburton D, Turcatel G, Mesenchyme-specific deletion of Tgf-beta1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasia. Lab Invest. 2019 Apr 25;
1	J:237505 Norrie JL, Li Q, Co S, Huang BL, Ding D, Uy JC, Ji Z, Mackem S, Bedford MT, Galli A, Ji H, Vokes SA, PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development. 2016 Dec 15;143(24):4608-4619
1	J:166455 Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK, BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci. 2010 Nov 10;30(45):15044-51
1*	J:90465 Ozeki H, Kurihara Y, Tonami K, Watatani S, Kurihara H, Endothelin-1 regulates the dorsoventral branchial arch patterning in mice. Mech Dev. 2004 Apr;121(4):387-95
1	J:135125 Pajni-Underwood S, Wilson CP, Elder C, Mishina Y, Lewandoski M, BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling. Development. 2007 Jun;134(12):2359-68
1*	J:77812 Perriton CL, Powles N, Chiang C, Maconochie MK, Cohn MJ, Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev Biol. 2002 Jul 1;247(1):26-46
1	J:163666 Prochazka J, Pantalacci S, Churava S, Rothova M, Lambert A, Lesot H, Klein O, Peterka M, Laudet V, Peterkova R, Patterning by heritage in mouse molar row development. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15497-502
1	J:165575 Puskaric S, Schmitteckert S, Mori AD, Glaser A, Schneider KU, Bruneau BG, Blaschke RJ, Steinbeisser H, Rappold G, Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart. Hum Mol Genet. 2010 Dec 1;19(23):4625-33
1	J:216214 Raspopovic J, Marcon L, Russo L, Sharpe J, Modeling digits. Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients. Science. 2014 Aug 1;345(6196):566-70
1*	J:153643 Self M, Geng X, Oliver G, Six2 activity is required for the formation of the mammalian pyloric sphincter. Dev Biol. 2009 Oct 15;334(2):409-17
1	J:281204 Sen R, Pezoa SA, Carpio Shull L, Hernandez-Lagunas L, Niswander LA, Artinger KB, Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice. J Dev Biol. 2018 Nov 12;6(4)
1	J:119477 Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch R, Jacks T, Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev. 2007 Mar 15;21(6):694-707
1	J:154460 Suzuki D, Yamada A, Amano T, Yasuhara R, Kimura A, Sakahara M, Tsumaki N, Takeda S, Tamura M, Nakamura M, Wada N, Nohno T, Shiroishi T, Aiba A, Kamijo R, Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development. Dev Biol. 2009 Nov 15;335(2):396-406
1	J:87225 Suzuki K, Bachiller D, Chen YP, Kamikawa M, Ogi H, Haraguchi R, Ogino Y, Minami Y, Mishina Y, Ahn K, Crenshaw EB 3rd, Yamada G, Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia: development by concerted actions of BMP signaling. (Erratum). Development. 2003 Dec;130(25):6209-20
1	J:54315 Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S, Limb and skin abnormalities in mice lacking IKKalpha [see comments]. Science. 1999 Apr 9;284(5412):313-6
1	J:157263 Talamillo A, Delgado I, Nakamura T, de-Vega S, Yoshitomi Y, Unda F, Birchmeier W, Yamada Y, Ros MA, Role of Epiprofin, a zinc-finger transcription factor, in limb development. Dev Biol. 2010 Jan 15;337(2):363-74
1*	J:59923 Tole S, Ragsdale CW, Grove EA, Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev Biol. 2000 Jan 15;217(2):254-65
1*	J:261953 Wang C, Wang J, Borer JG, Li X, Embryonic origin and remodeling of the urinary and digestive outlets. PLoS One. 2013;8(2):e55587
1	J:212095 Wang J, Bai Y, Li N, Ye W, Zhang M, Greene SB, Tao Y, Chen Y, Wehrens XH, Martin JF, Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9181-6
1	J:154916 Welsh IC, O'Brien TP, Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate. Dev Biol. 2009 Dec 1;336(1):53-67
1	J:107406 White AC, Xu J, Yin Y, Smith C, Schmid G, Ornitz DM, FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development. 2006 Apr;133(8):1507-17
1*	J:182768 Wong YL, Behringer RR, Kwan KM, Smad1/Smad5 signaling in limb ectoderm functions redundantly and is required for interdigital programmed cell death. Dev Biol. 2012 Mar 1;363(1):247-57
1	J:306208 Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X, FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. BMC Biol. 2020 Jul 14;18(1):87
1*	J:202865 Yang T, Bassuk AG, Fritzsch B, Prickle1 stunts limb growth through alteration of cell polarity and gene expression. Dev Dyn. 2013 Nov;242(11):1293-306
1	J:175543 Yin Y, Wang F, Ornitz DM, Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development. Development. 2011 Aug;138(15):3169-77
1	J:178188 Zhang J, Chang JY, Huang Y, Lin X, Luo Y, Schwartz RJ, Martin JF, Wang F, The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation. Circ Res. 2010 Nov 12;107(10):1209-19
1	J:104353 Zhang X, Stappenbeck TS, White AC, Lavine KJ, Gordon JI, Ornitz DM, Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development. 2006 Jan;133(1):173-80
1*	J:60837 Zhang Y, Zhang Z, Zhao X, Yu X, Hu Y, Geronimo B, Fromm SH, Chen YP, A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ. Development. 2000 Apr;127(7):1431-43
1*	J:175832 Zhao F, Bosserhoff AK, Buettner R, Moser M, A heart-hand syndrome gene: Tfap2b plays a critical role in the development and remodeling of mouse ductus arteriosus and limb patterning. PLoS One. 2011;6(7):e22908
1*	J:139188 Zhao H, Oka K, Bringas P, Kaartinen V, Chai Y, TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol. 2008 Aug 1;320(1):19-29
1	J:205040 Zhou J, Gao Y, Lan Y, Jia S, Jiang R, Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development. 2013 Dec;140(23):4709-18